Plasmodium falciparum ATP4 (PfATP4) is a Na + efflux pump and represents an important target for antimalarial drugs with nanomolar potency. However, the structure of PfATP4 is unknown, prompting the development of new methodologies to ...Among new antimalarials discovered over the past decade are multiple chemical scaffolds that target Plasmodium falciparum P-type ATPase (PfATP4).

Cover image: Pictured are cattle herders in Ethiopia. A collection of articles in the Sustainability of Animal-Sourced Foods and Plant-Based Alternatives Special Feature explores the contributions of animal-sourced foods to human nutrition and health, the environmental impact of animal-sourced foods, and the potential of plant-based alternatives to …

Dec 17, 2024 · Browse the most-recent publications from PNAS, publishing daily across the physical, social, and biological sciences.

Cities can support diverse communities of plants and animals, and access to nature is recognized as a key component of making cities functional and livable places for people (6–8).However, when urban land replaces natural habitat, it permanently alters the type of habitats available, along with their spatial configuration and level of interconnectedness, resulting in significant changes in ...

The article explores the impact of economic globalization on land conversion and forest cover in developing countries.

Cellular organization is a key characteristic of life as we know it. Living organisms are made of cells, i.e., tiny, self-contained, self-regulated units surrounded by a membrane that allows the transfer of mass and energy with their neighbors and the surrounding environment (1–3).Although liquid–liquid demixing could lead to membraneless coacervates and …

A detailed retrospective of the Green Revolution, its achievements and limits in agricultural productivity, and its broader social, environmental, and economic impacts.

Gene Set Enrichment Analysis (GSEA) is a powerful method for interpreting gene expression data by focusing on groups of genes with common functions.

A PDF list of Editorial Board members and staff members is posted on the current issue Table of Contents; click on the [Masthead (PDF)] link in the upper right corner.

Proceedings of the National Academy of Sciences (PNAS) publishes high-impact scientific research across a wide range of disciplines.